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Dr. Bremers Research
In addition to practicing as a podiatrist in St. Clair County, MI, Dr. Bremer also works as a research associate at Dr Henry Heng’s Cytogenetic lab located at the Center for Molecular Medicine and Genetics, Wayne State Medical School, Detroit, MI.  The lab currently focuses on cytogenetic technologies called Spectral Karyotyping (SKY) that are used to detect molecular changes in the chromosomal structure of cells.  The lab is currently funded by the Susan G. Komen Breast Cancer Foundation and is working on the molecular analysis and detection of patients that are predisposed to developing cancer transformation.

 

Legend: Computer enhanced SKY karyograms of actual chromosomes from two human breast cells just prior to cancer transformation.  Normal human cells have 1 pair of each chromosome (23 pairs, 46 total) each pair with a single unique color.  These cells have more than 2 of the same chromosomes plus many chromosomes have two or three colors indicating a shuffling of chromosomal material.  These alterations are caused by underlying genetic instability and indicate that cancer transformation is imminent.


Dr Bremer’s current publications
Source: Pubmed: http://www.ncbi.nlm.nih.gov/PubMed/
Pubmed is a service of the U.S. National Library of Medicine  and the National Institutes of Health

Publications:
Bremer SW. (1985) The unstable ankle mortise--functional ankle varus. J Foot Surg. 24:313-7.
Bremer SW (1981) Diagnosis and treatment of ankle pain and instability. J Foot Surg. 20:88-90
Heng HH, Stevens JB, Lawrenson L, Liu G, Ye KJ, Bremer SW, Ye CJ. Patterns of genome dynamics and cancer evolution.
     Cell Oncol. 2008;30(6):513-4
Heng HH, Stevens JB, Liu G, Bremer SW, Ye CJ. (2004) Imaging genome abnormalities in cancer research.
     Cell Chromosome. 3:1.
Heng HH, Ye CJ, Yang F, Ebrahim S, Liu G, Bremer SW, Thomas CM, Ye J, Chen TJ, Tuck-Muller C, Yu JW, Krawetz SA,  
     Johnson A. (2003) Analysis of marker or complex chromosomal rearrangements present in pre- and post-natal karyotypes 
     utilizing a combination of G-banding, spectral karyotyping and fluorescence in situ hybridization. Clin Genet. 63:358-67.
Heng, H.H., Bremer, S.W., Stevens, J., Ye, K.J., Miller, F., Liu, G., Ye, C.J. 2006. Editorial perspective: Cancer progression by 
     non-clonal chromosome aberrations. J Cellular Biochemistry 98:1424-1435 (featured on the cover page).
Heng, H.H.Q., Stevens, J., Gou Liu, Wu, G-S, Bremer, S.W., Ye, J, Wang AY., Tainsky, M, Reddy P and Ye, CJ. 2006. 
     Stochastic cancer progression driven by non-clonal chromosome aberrations. J Cellular Physiology 208:461-472.
Heng H, Goetze S, Ye CJ, Lu W, Liu G, Bremer SW, Hughes M, Bode J, Krawetz SA. (2004) Chromatin loops are anchored 
     using S/MAR selection. J Cell Sci. 117:999-1008.
Heng HH, Bremer SW, Stevens JB, Ye KJ, Liu G, Ye CJ. Genetic and epigenetic heterogeneity in cancer: A genome-centric
     perspective. J Cell Physiol. 2009 May 13. [Epub ahead of print]
Heng HH, Krawetz SA, Lu W, Bremer S, Liu G, Ye CJ. (2001) Re-defining the chromatin loop domain. Cytogenet Cell Genet.
     93:155-61.
Heng HH, Liu G, Lu W, Bremer SW, Ye CJ, Hughes M, Moens P. (2001) Spectral karyotyping (SKY) of mouse meiotic 
     chromosomes. Genome. 44:293-8.
Heng, H.H., Liu, G., Bremer, S.W., Ye, K.J., Stevens, J., and Ye, C.J. 2006. Clonal and Non Clonal Chromosome Aberrations  
     and Genome Variation/Aberration. Genome 49:195-204.
Liu G, Lu W, Bremer SW, Hameister H, Schreiner B, Hughes M, Heng HH. (2000) Spectral karyotyping of mouse cell line WMP2.
     Cytogenet Cell Genet. 90:271-4.
Stevens JB, Liu G, Bremer SW, Ye KJ, Xu W, Xu J, Sun Y, Wu GS, Savasan S, Krawetz SA, Ye CJ, Heng HH. (2007) Mitotic
     cell death by chromosome fragmentation. Cancer Res. 67:7686-94.
Ye CJ, Liu G, Bremer SW, Heng HH. (2007) The dynamics of cancer chromosomes and genomes. Cytogenet Genome Res.
     118:237-46.
Ye CJ, Lu W, Liu G, Bremer SW, Wang YA, Moens P, Hughes M, Krawetz SA, Heng HH. (2001) The combination of SKY and
     specific loci detection with FISH or immunostaining. Cytogenet Cell Genet. 93:195-202.
Ye CJ, Stevens JB, Liu G, Bremer SW, Jaiswal AS, Ye KJ, Lin MF, Lawrenson L, Lancaster WD, Kurkinen M, Liao JD, Gairola CG,
     Shekhar MP, Narayan S, Miller FR, Heng HH. Genome based cell population heterogeneity promotes tumorigenicity: the 
     evolutionary mechanism of cancer. J Cell Physiol. 2009 May;219(2):288-300.
Ye CJ, Stevens JB, Liu G, Ye KJ, Yang F, Bremer SW, Heng HH. Combined multicolor-FISH and immunostaining. Cytogenet
     Genome Res. 2006;114(3-4):227-34.




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